Fomichev A.V.   Чернявский А.М.  

Bone marrow cells implantation in laser channels in IHD surgery

Reporter: Fomichev A.V.

Finding an indirect myocardial revascularization effective method is topical at the moment. Data from 35 coronary heart disease (CHD) patients after intramyocardial bone marrow cells (BMC) implantation were analyzed. The functional class (FC) New York Heart Association (NYHA) mean value in the BMC group decreased from 2.57 ± 0.61 preoperatively to 1.77 ± 0.66 six months after surgery (p = 0.043). FC (NYHA) six years after surgery: 1.84 ± 0.42 (p = 0.053). According to perfusion scintigraphy, the stable perfusion defect (SPD) before surgery was 20.46% ± 10.75%, 19.07% ± 9.69% two weeks after the operation, and 15.22% ± 9.49% after six months. Six years after surgery, SPD was 14.8% ± 8.43% (p = 0.047). Transient perfusion defects decreased from 30% ± 2.2% to 15% ± 1.3% at six months, and 20% ± 6.1% in the long term (p = 0.047). The average value of left ventricular ejection fraction before surgery was 55% ± 10.4%, 55.7% ± 9.3% two weeks after the operation, 56.7% ± 10% at six months, and 54% ± 12% after six years (p = 0.068). The indirect revascularization effect is formed in the six months after surgery and remains at the same level for six years.

Funding:
This work was supported by a Russian Scientific Foundation grant (project number 16-15-00057).


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